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New Releases from NCBI BookshelfInfliximab (Remsima SC): CADTH Reimbursement Recommendation: Indication: For the maintenance treatment of adults with moderately to severely active Crohn’s disease who have had an inadequate response or were intolerant to conventional therapy. Remsima SC should only be used as maintenance therapy after the completion of an induction period with intravenous infliximab [Internet].​Infliximab (Remsima SC): CADTH Reimbursement Recommendation: Indication: For the maintenance treatment of adults with moderately to severely active Crohn’s disease who have had an inadequate response or were intolerant to conventional therapy. Remsima SC should only be used as maintenance therapy after the completion of an induction period with intravenous infliximab [Internet].

CADTH recommends that Remsima SC be reimbursed by public drug plans as maintenance treatment for adults with moderately to severely

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New Releases from NCBI BookshelfMetreleptin (Myalepta): CADTH Reimbursement Recommendation: Indication: As an adjunct to diet as a replacement therapy to treat the complications of leptin deficiency in lipodystrophy (LD) patients: with confirmed congenital generalised LD (Berardinelli-Seip syndrome) or acquired generalised LD (Lawrence syndrome) in adults and children 2 years of age and above with confirmed familial partial LD (PL) or acquired PL (Barraquer-Simons syndrome), in adults and children 12 years of age and above with persistent significant metabolic disease for whom standard treatments have failed to achieve adequate metabolic control [Internet].​Metreleptin (Myalepta): CADTH Reimbursement Recommendation: Indication: As an adjunct to diet as a replacement therapy to treat the complications of leptin deficiency in lipodystrophy (LD) patients: with confirmed congenital generalised LD (Berardinelli-Seip syndrome) or acquired generalised LD (Lawrence syndrome) in adults and children 2 years of age and above with confirmed familial partial LD (PL) or acquired PL (Barraquer-Simons syndrome), in adults and children 12 years of age and above with persistent significant metabolic disease for whom standard treatments have failed to achieve adequate metabolic control [Internet].

We recommend that Myalepta should be reimbursed by public drug plans as an adjunct to diet as a replacement therapy

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New Releases from NCBI BookshelfEtranacogene Dezaparvovec (Hemgenix): CADTH Reimbursement Recommendation: Indication: For treatment of adults (aged 18 years of age or older) with Hemophilia B (congenital factor IX deficiency) who require routine prophylaxis to prevent or reduce the frequency of bleeding episodes [Internet].​Etranacogene Dezaparvovec (Hemgenix): CADTH Reimbursement Recommendation: Indication: For treatment of adults (aged 18 years of age or older) with Hemophilia B (congenital factor IX deficiency) who require routine prophylaxis to prevent or reduce the frequency of bleeding episodes [Internet].

CADTH recommends that public drug plans reimburse Hemgenix for the treatment of hemophilia B if certain conditions are met. ​ 

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New Releases from NCBI BookshelfMaralixibat (Livmarli): CADTH Reimbursement Recommendation: Indication: For the treatment of cholestatic pruritus in patients with Alagille syndrome [Internet].​Maralixibat (Livmarli): CADTH Reimbursement Recommendation: Indication: For the treatment of cholestatic pruritus in patients with Alagille syndrome [Internet].

CADTH recommends that Livmarli should be reimbursed by public drug plans for the treatment of cholestatic pruritus in patients with

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New Releases from NCBI BookshelfAlemtuzumab, Cladribine, Fingolimod, Natalizumab, and Rituximab as First-Line Treatments in Adults With Highly Active Relapsing-Remitting Multiple Sclerosis: Health Technology Assessment [Internet].​Alemtuzumab, Cladribine, Fingolimod, Natalizumab, and Rituximab as First-Line Treatments in Adults With Highly Active Relapsing-Remitting Multiple Sclerosis: Health Technology Assessment [Internet].

Relapsing-remitting multiple sclerosis (RRMS), the most common disease course of multiple sclerosis (MS), is a chronic immune-mediated disease with clearly

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New Releases from NCBI BookshelfAnticytokine Therapy and Corticosteroids for Cytokine Release Syndrome and for Neurotoxicity Following T-Cell Engager or CAR T-Cell Therapy: Rapid Review [Internet].​Anticytokine Therapy and Corticosteroids for Cytokine Release Syndrome and for Neurotoxicity Following T-Cell Engager or CAR T-Cell Therapy: Rapid Review [Internet].

Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are the most common toxicities secondary to T-cell engager

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