The rise of patient-centered effectiveness research and the movement toward learning health systems has raised questions about the appropriateness of traditional informed consent in the context of different learning activities. Cogent moral arguments exist to streamline informed consent for low-risk comparative effectiveness research (CER) studies. Several recent empirical studies examining stakeholder perspectives regarding consent approaches for low-risk CER suggest that patients may be willing to move toward a streamlined model, at least for some types of low-risk CER studies. In this study, we used experimental survey methods to explore attitudes regarding streamlined consent approaches, and the impact of additional respect-promoting components on attitudes toward CER and informed consent.
