Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can modify sickle cell disease (SCD), reduce complications, and improve survival; however, these treatments are associated with a significant decisional dilemma because of the inherent risk–benefit tradeoffs and the lack of comparative studies. These treatments are underutilized, leading to avoidable morbidity and premature mortality. A web-based decision aid has the potential to provide patients high-quality information about their treatment options and the associated risks and benefits, help them clarify their values, and allow them to share in the process of informed medical decision-making.
