New Releases from NCBI BookshelfInclisiran (Leqvio): CADTH Reimbursement Recommendation: Indication: For use as an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with non-familial hypercholesterolemia with atherosclerotic cardiovascular disease who are on maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies [Internet].​Inclisiran (Leqvio): CADTH Reimbursement Recommendation: Indication: For use as an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with non-familial hypercholesterolemia with atherosclerotic cardiovascular disease who are on maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies [Internet].

CADTH recommends that Leqvio not be reimbursed by public drug plans as an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) levels in adults who are on a maximally tolerated dose (MTD) of a statin, with or without other LDL-C–lowering therapies, and who have nonfamilial hypercholesterolemia (nFH) with atherosclerotic cardiovascular disease (ASCVD).

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