Several existing systematic reviews have examined the use of ketamine in the prehospital setting for acute pain, sedation, and RSI and have generally found that ketamine is safe and effective when used appropriately. However, these reviews have largely included studies conducted in the emergency department (ED) and extrapolated findings to the prehospital setting. More evidence specific to the prehospital setting is becoming available as EMS providers seek to improve guidance for the field and ensure the safety of EMS treatment protocols.
