Soft tissue sarcomas are a heterogeneous group of rare tumours in muscle, adipose, fibrous, cartilage, nerve, and vascular tissue. Leiomyosarcoma is the most frequent subtype of soft tissue sarcoma that originates in smooth muscle, such as the gastrointestinal tract, large blood vessels, or the uterus, and it commonly spreads to the liver, lung, upper abdomen, and pelvis. The rarity and heterogeneity of leiomyosarcoma impact patients’ ability to receive timely and accurate diagnoses; access support services, including specialized health care providers; and receive timely and appropriate treatment. Patients with soft tissue sarcoma commonly present with a gradually enlarging, painless mass and may develop pain or symptoms due to compression by the mass. Patients with uterine leiomyosarcoma present with a uterine mass and can experience no symptoms to abnormal uterine bleeding, abdominal distension or pain, and pelvic pain or pressure.
