Non-contrast computed tomography has low sensitivity to brain ischaemia. Higher sensitivity of computed tomography perfusion and computed tomography angiography may identify more thrombolysis-eligible patients, but the role of these imaging modalities in thrombolysis treatment decisions within 4.5 hours is unclear. We hypothesised that multimodal computed tomography (non-contrast computed tomography + computed tomography angiography + computed tomography perfusion) would modify treatment decisions with net increase in thrombolysis rates.
