July 10, 2024

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New Releases from NCBI BookshelfMaralixibat (Livmarli): CADTH Reimbursement Recommendation: Indication: For the treatment of cholestatic pruritus in patients with Alagille syndrome [Internet].​Maralixibat (Livmarli): CADTH Reimbursement Recommendation: Indication: For the treatment of cholestatic pruritus in patients with Alagille syndrome [Internet].

CADTH recommends that Livmarli should be reimbursed by public drug plans for the treatment of cholestatic pruritus in patients with

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New Releases from NCBI BookshelfEtranacogene Dezaparvovec (Hemgenix): CADTH Reimbursement Recommendation: Indication: For treatment of adults (aged 18 years of age or older) with Hemophilia B (congenital factor IX deficiency) who require routine prophylaxis to prevent or reduce the frequency of bleeding episodes [Internet].​Etranacogene Dezaparvovec (Hemgenix): CADTH Reimbursement Recommendation: Indication: For treatment of adults (aged 18 years of age or older) with Hemophilia B (congenital factor IX deficiency) who require routine prophylaxis to prevent or reduce the frequency of bleeding episodes [Internet].

CADTH recommends that public drug plans reimburse Hemgenix for the treatment of hemophilia B if certain conditions are met. ​ 

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New Releases from NCBI BookshelfMetreleptin (Myalepta): CADTH Reimbursement Recommendation: Indication: As an adjunct to diet as a replacement therapy to treat the complications of leptin deficiency in lipodystrophy (LD) patients: with confirmed congenital generalised LD (Berardinelli-Seip syndrome) or acquired generalised LD (Lawrence syndrome) in adults and children 2 years of age and above with confirmed familial partial LD (PL) or acquired PL (Barraquer-Simons syndrome), in adults and children 12 years of age and above with persistent significant metabolic disease for whom standard treatments have failed to achieve adequate metabolic control [Internet].​Metreleptin (Myalepta): CADTH Reimbursement Recommendation: Indication: As an adjunct to diet as a replacement therapy to treat the complications of leptin deficiency in lipodystrophy (LD) patients: with confirmed congenital generalised LD (Berardinelli-Seip syndrome) or acquired generalised LD (Lawrence syndrome) in adults and children 2 years of age and above with confirmed familial partial LD (PL) or acquired PL (Barraquer-Simons syndrome), in adults and children 12 years of age and above with persistent significant metabolic disease for whom standard treatments have failed to achieve adequate metabolic control [Internet].

We recommend that Myalepta should be reimbursed by public drug plans as an adjunct to diet as a replacement therapy

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New Releases from NCBI BookshelfInfliximab (Remsima SC): CADTH Reimbursement Recommendation: Indication: For the maintenance treatment of adults with moderately to severely active Crohn’s disease who have had an inadequate response or were intolerant to conventional therapy. Remsima SC should only be used as maintenance therapy after the completion of an induction period with intravenous infliximab [Internet].​Infliximab (Remsima SC): CADTH Reimbursement Recommendation: Indication: For the maintenance treatment of adults with moderately to severely active Crohn’s disease who have had an inadequate response or were intolerant to conventional therapy. Remsima SC should only be used as maintenance therapy after the completion of an induction period with intravenous infliximab [Internet].

CADTH recommends that Remsima SC be reimbursed by public drug plans as maintenance treatment for adults with moderately to severely

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New Releases from NCBI BookshelfCannabidiol (Epidiolex): CADTH Reimbursement Recommendation: Indication: Use as adjunctive therapy for the treatment of seizures associated with Dravet Syndrome in patients 2 years of age and older [Internet].​Cannabidiol (Epidiolex): CADTH Reimbursement Recommendation: Indication: Use as adjunctive therapy for the treatment of seizures associated with Dravet Syndrome in patients 2 years of age and older [Internet].

CADTH recommends that Epidiolex be reimbursed by public drug plans for the adjunctive therapy of seizures associated with Dravet syndrome

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New Releases from NCBI BookshelfInclisiran (Leqvio): CADTH Reimbursement Recommendation: Indication: For use as an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with non-familial hypercholesterolemia with atherosclerotic cardiovascular disease who are on maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies [Internet].​Inclisiran (Leqvio): CADTH Reimbursement Recommendation: Indication: For use as an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with non-familial hypercholesterolemia with atherosclerotic cardiovascular disease who are on maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies [Internet].

CADTH recommends that Leqvio not be reimbursed by public drug plans as an adjunct to lifestyle changes, including diet, to

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New Releases from NCBI BookshelfTralokinumab (Adtralza): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate-to-severe atopic dermatitis in adult and adolescent patients 12 years and older whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Tralokinumab can be used with or without topical corticosteroids [Internet].​Tralokinumab (Adtralza): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate-to-severe atopic dermatitis in adult and adolescent patients 12 years and older whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Tralokinumab can be used with or without topical corticosteroids [Internet].

CADTH recommends that Adtralza should not be reimbursed by public drug plans for the treatment of moderate to severe atopic

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